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Year Number of Results
1915 1
1946 4
1947 3
1948 2
1950 1
1951 2
1952 1
1953 1
1954 2
1956 1
1957 1
1958 1
1959 3
1960 6
1961 7
1962 1
1963 6
1964 13
1965 14
1966 16
1967 13
1968 37
1969 20
1970 23
1971 26
1972 27
1973 24
1974 30
1975 96
1976 85
1977 64
1978 68
1979 81
1980 90
1981 75
1982 112
1983 85
1984 118
1985 116
1986 152
1987 153
1988 153
1989 156
1990 212
1991 223
1992 229
1993 222
1994 221
1995 217
1996 260
1997 237
1998 268
1999 287
2000 361
2001 399
2002 447
2003 445
2004 429
2005 497
2006 496
2007 568
2008 568
2009 509
2010 593
2011 647
2012 627
2013 594
2014 625
2015 641
2016 625
2017 681
2018 664
2019 622
2020 697
2021 684
2022 564
2023 592
2024 222

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16,915 results

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Page 1
Alkylating Agents.
[No authors listed] [No authors listed] 2015 Mar 10. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2015 Mar 10. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643188 Free Books & Documents. Review.
Alkylating agents substitute alkyl groups for hydrogen atoms on DNA, resulting in the formation of cross links within the DNA chain and thereby resulting in cytotoxic, mutagenic, and carcinogenic effects. This action occurs in all cells, but alkylat …
Alkylating agents substitute alkyl groups for hydrogen atoms on DNA, resulting in the formation of cross links w …
[Alkyl-substituted benzo-pyrido-thiazoles].
Haller R, Hawlitzky N. Haller R, et al. Arch Pharm Ber Dtsch Pharm Ges. 1971 May;304(5):367-74. doi: 10.1002/ardp.19713040509. Arch Pharm Ber Dtsch Pharm Ges. 1971. PMID: 5284163 German. No abstract available.
Ion Pair Catalyst - Pentanidinium.
Qin Y, Zhang Z, Ye X, Tan CH. Qin Y, et al. Chem Rec. 2023 Jul;23(7):e202200304. doi: 10.1002/tcr.202200304. Epub 2023 Feb 10. Chem Rec. 2023. PMID: 36762723 Review.
We have confirmed that pentanidinium can catalyze alpha-hydroxylation of 3-substituted-2-oxindoles, Michael addition of 3-alkyloxindoles with vinyl sulfone, and alkylation reactions of sulfenate anions and dihydrocoumarins, desymmetrization of pro-chiral sulfinate t …
We have confirmed that pentanidinium can catalyze alpha-hydroxylation of 3-substituted-2-oxindoles, Michael addition of 3-alkyloxindo …
Unified Approach to Benzo[d]thiazol-2-yl-Sulfonamides.
Zálešák F, Kováč O, Lachetová E, Št'astná N, Pospíšil J. Zálešák F, et al. J Org Chem. 2021 Sep 3;86(17):11291-11309. doi: 10.1021/acs.joc.1c00317. Epub 2021 Aug 16. J Org Chem. 2021. PMID: 34479409
The labile N-H bond in N-monoalkylated BT-sulfonamides (pK(a) (BTSO(2)N(H)Bn) = 3.34 0.05) further allowed us to develop a simple weak base-promoted N-alkylation method and a stereoselective microwave-promoted Fukuyama-Mitsunobu reaction. N-Alkyl-N-aryl BT-sulfonami …
The labile N-H bond in N-monoalkylated BT-sulfonamides (pK(a) (BTSO(2)N(H)Bn) = 3.34 0.05) further allowed us to develop a simple weak base- …
Catalytic asymmetric alkylations of ketoimines. Enantioselective synthesis of N-substituted quaternary carbon stereogenic centers by Zr-catalyzed additions of dialkylzinc reagents to aryl-, alkyl-, and trifluoroalkyl-substituted ketoimines.
Fu P, Snapper ML, Hoveyda AH. Fu P, et al. J Am Chem Soc. 2008 Apr 23;130(16):5530-41. doi: 10.1021/ja8001343. Epub 2008 Apr 1. J Am Chem Soc. 2008. PMID: 18376838
Catalytic enantioselective alkylations of three classes of ketoimines are reported. Reactions are promoted in the presence 0.5-10 mol % of a Zr salt and a chiral ligand that contains two inexpensive amino acids (valine and phenylalanine) and involve Me2Zn or Et2Zn as al …
Catalytic enantioselective alkylations of three classes of ketoimines are reported. Reactions are promoted in the presence 0.5-10 mol …
SO(2)F(2)-Mediated N-Alkylation of Imino-Thiazolidinones.
Santos L, Donnard M, Panossian A, Vors JP, Jeschke P, Bernier D, Pazenok S, Leroux FR. Santos L, et al. J Org Chem. 2022 Feb 18;87(4):2012-2021. doi: 10.1021/acs.joc.1c01247. Epub 2021 Aug 6. J Org Chem. 2022. PMID: 34355900
The N-alkylation of ambident and weakly nucleophilic imino-thiazolidinones has been developed via substitution with alkyl fluorosulfonates. ...The use of electron-withdrawing groups and DMAc as solvent affords a (Z)- and N-endocyclic selectivity for the easy …
The N-alkylation of ambident and weakly nucleophilic imino-thiazolidinones has been developed via substitution with alkyl …
Alkylation of 5-Substituted 1H-Tetrazoles via the Diazotization of Aliphatic Amines.
Reynard G, Lebel H. Reynard G, et al. J Org Chem. 2021 Sep 3;86(17):12452-12459. doi: 10.1021/acs.joc.1c01585. Epub 2021 Aug 17. J Org Chem. 2021. PMID: 34479404
A new alkylation reaction of monosubstituted tetrazoles via the diazotization of aliphatic amines is reported. ...The reaction conditions were compatible with several functional groups, including thiocyanates, which afford preferentially disubstituted 2-alkyl-5-( …
A new alkylation reaction of monosubstituted tetrazoles via the diazotization of aliphatic amines is reported. ...The reaction condit …
Synthesis of Boron-Containing Nucleoside Analogs.
Alhthlol LM, Orme CL, Jefferis BS, Herter SA, Kemper HE, Tomsho JW. Alhthlol LM, et al. J Org Chem. 2024 Feb 2;89(3):1556-1566. doi: 10.1021/acs.joc.3c02179. Epub 2024 Jan 16. J Org Chem. 2024. PMID: 38227951 Free PMC article.
Herein, we report the synthesis, isolation, and characterization of two novel boron-containing nucleoside compound libraries which may find utility as therapeutic agents. Our synthetic strategy employs efficient one-step substitution reactions between a diverse vari …
Herein, we report the synthesis, isolation, and characterization of two novel boron-containing nucleoside compound libraries which may find …
Synthesis of 2'-O-substituted ribonucleosides.
Serebryany V, Beigelman L. Serebryany V, et al. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1007-9. doi: 10.1081/NCN-120022724. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565332
An efficient synthesis of 2'-O-substituted ribonucleosides, including 2'-O-TBDMS and 2'-O-TOM protected as well as 2'-O-Me and 2'-O-allyl derivatives is presented. Di-t-butylsilylene group was employed for simultaneous protection of 3'- and 5'- hydroxyl functions of nucleo …
An efficient synthesis of 2'-O-substituted ribonucleosides, including 2'-O-TBDMS and 2'-O-TOM protected as well as 2'-O-Me and 2'-O-a …
Copper-catalysed enantioconvergent alkylation of oxygen nucleophiles.
Chen C, Fu GC. Chen C, et al. Nature. 2023 Jun;618(7964):301-307. doi: 10.1038/s41586-023-06001-y. Epub 2023 Mar 30. Nature. 2023. PMID: 36996870
The Williamson ether synthesis, first reported in 1850(1), is the most widely used approach to the alkylation of an oxygen nucleophile, but it has significant limitations (scope and stereochemistry) owing to its reaction mechanism (S(N)2 pathway). ...The catalyst is unique …
The Williamson ether synthesis, first reported in 1850(1), is the most widely used approach to the alkylation of an oxygen nucleophil …
16,915 results
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